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Hypoxia & altitude adaptations in Ethiopia highlands

Discussion in 'Freediving Science' started by wet, Nov 15, 2012.

  1. wet

    wet Freediver82 - water borne

  2. wet

    wet Freediver82 - water borne

    Uric acid, Ascorbic acid, Fructose effects:

    Basically it turns out that uric acid triggers hibernation and fat storage
    in many animals also. My take is that in Northern Europe and other
    non-tropic places, fructose was mainly available only in the fall, when
    fruits became ripe, and humans (and bears) stored fat for the winter.
    [Heather Sweet at AAT]

    Theodore E. Woodward Award: The Evolution of Obesity: Insights from the Mid- Miocene

    All humans are double knockouts. Humans lack the ability to synthesize
    vitamin C due to a mutation in L-gulono-lactone oxidase that occurred
    during the late Eocene, and humans have higher serum uric acid levels due
    to a mutation in uricase that occurred in the mid Miocene. In this paper we
    review the hypothesis that these mutations have in common the induction of
    oxidative stress that may have had prosurvival effects to enhance the
    effects of fructose to increase fat stores. Fructose was the primary
    nutrient in fruit which was the main staple of early primates, but this
    food likely became less available during the global cooling that occurred
    at the time of these mutations. However, in today's society, the intake of
    fructose, primarily in the form of added sugars, has skyrocketed, while the
    intake of natural fruits high in vitamin C has fallen. We suggest that it
    is the interaction of these genetic changes with diet that is responsible
    for the obesity epidemic today. Hence, we propose that Neel's thrifty gene
    hypothesis is supported by these new insights into the mechanisms
    regulating fructose metabolism. (cite at AAT)

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