Well Dr Alun,
I remember reading comments like that about 4-5 years ago, and thinking - Wow! Then I realised that it was more of an issue of lung tissue becoming erect, rather than actually filling plasma.
Now, if I jog my feeble memory back into physiology mode - It would take a change in osmotic pressure for plasma to enter the lung air-spaces - and a big one at that. Capilliaires would rupture before the necessary physical pressure was reached to force blood plasma through at the kind of rate implied here.
People may compare this scenario to pulmonary oedema (sp?) at extreme altitudes - but that needs time to occur, or an extremely low pressure - and it is different. In that case the absolute pressure drops externally and the internal blood pressure tries to remain as it is. Thereby making an increased gradient.
In our instance - the pressure of air in the lungs gets higher and the RELATIVE difference between absolute blood pressure and absolute lung air pressure reduces. To get any transfer of blood plasma across the membrane there would need to be a big resistance to compression by the ribs and diaphragm which would allow the blood pressure to be high and the lung pressure to be lower than normal.
Alternatively, there could be an alteration in membrane function at pressure. This does happen, but I seem to remember that it needs a lot more absolute pressure i.e. at least 200 bar.
:hungover
I remember reading comments like that about 4-5 years ago, and thinking - Wow! Then I realised that it was more of an issue of lung tissue becoming erect, rather than actually filling plasma.
Now, if I jog my feeble memory back into physiology mode - It would take a change in osmotic pressure for plasma to enter the lung air-spaces - and a big one at that. Capilliaires would rupture before the necessary physical pressure was reached to force blood plasma through at the kind of rate implied here.
People may compare this scenario to pulmonary oedema (sp?) at extreme altitudes - but that needs time to occur, or an extremely low pressure - and it is different. In that case the absolute pressure drops externally and the internal blood pressure tries to remain as it is. Thereby making an increased gradient.
In our instance - the pressure of air in the lungs gets higher and the RELATIVE difference between absolute blood pressure and absolute lung air pressure reduces. To get any transfer of blood plasma across the membrane there would need to be a big resistance to compression by the ribs and diaphragm which would allow the blood pressure to be high and the lung pressure to be lower than normal.
Alternatively, there could be an alteration in membrane function at pressure. This does happen, but I seem to remember that it needs a lot more absolute pressure i.e. at least 200 bar.
:hungover
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